The junction between the Murchison and Bass Highways will be closed for up to two and half months from Monday while it undergoes a major upgrade.
The Department of State Growth says the busy junction will be closed from Monday until December 18th, with work going on between 7 am and 6 pm daily.
The overhaul is part of the Cam River Bridge replacement project and will include widening the intersection and the installation of traffic lights.
A detour will be in place during the upgrade between Falmouth and Simpson Streets in Somerset.
A section of the Bass Highway on the Western side of the Cam River will also be reduced to one lane from Wednesday to Friday next week.
Details of road closures and detours, including maps, can be found on the Waratah-Wynyard Council Facebook page and the Department of State Growth website.